• 목록
• 답변
• 글쓰기
• 게시판 리스트 옵션
  • 수정
  • 삭제

Mal cellular elements were mutually interactive. Thus, GCSF appears to be a potential physiological marker of the functional integrity of the endometrium. Furthermore, it was demonstrated for the first time that administration of hCG could affect isolated endometrial epithelial cells, stromal cells and mixed cells in a differential fashion. Many of the factors are known to exert paracrine influence on implantation-stage endometrium (e.g., IFNG, IL-1b, IL-6 and TNF) and support embryo implantation (e.g., CCL3, CCL4, CCL5, FGF2, GCSF, IL-1b, IL-6, IL-8, LIF, PDGFbb, TNF PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/13485127 and VEGF) through their regulatory actions on inflammation, proliferation, cell adhesion, chemotaxis, apoptosis and immune responses during blastocyst implantation. It is thus apparent that embryo- and endometrial-derived CG can influence implantation-stage endometrial functions through complexSrivastava et al. Reproductive Biology and Endocrinology 2013, 11:116 http://www.rbej.com/content/11/1/Page 13 ofprocesses involving various cell types in the endometrium. Finally, this study provided a panel of specific cytokines, chemokines and growth factors that are secreted by various cell types in the endometrium during the window of implantation.7.Additional filesAdditional file 1: Table S1. Cytokines, chemokines and growth factors studied. Additional file 2: Table S2. Primary antibodies Phenyl (4-chloro-3-fluorophenyl)carbamate used in the study. Additional file 3: Table S3. List of genes and their primers used for quantitative real time RT-PCR. Additional file 4: Table S4. Profiles of secreted cytokines, chemokines and growth factors from isolated endometrial cells of three culture groups in the basal condition. Competing interests The authors declare that they have no competing interests. Authors' contributions AKS contributed in performing experiments, data acquisition and data analysis. JS and DG contributed to the study design, acquisition, analysis and interpretation of data, and drafting of the manuscript. AK and KKR contributed in providing human samples and data interpretation. All authors read and approved the final manuscript. Acknowledgements The authors acknowledge the support of the Molecular Biology Laboratory and the Confocal Imaging Facility of the Department of Physiology, All India Institute of Medical Sciences. The authors thank Mr Harpal Rana for his support in the imaging procedures. The study was supported by the Department of Science and Technology, Government of India (Grant number D-244). The authors also acknowledge the support from the language editing service from Elsewier Language Editing. The authors 6-Bromopyridine-2,3-diamine are thankful to the reviewers for their critical and constructive comments and suggestions on the manuscript. Author details 1 Department of Physiology, All India Institute of Medical Sciences, New Delhi, India. 2Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India. 3Present address: Department of Physiology, North DMC Medical PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/13867361 College, Hindu Rao Hospital, New Delhi 110007, India. Received: 28 June 2013 Accepted: 10 December 2013 Published: 17 December 2013 References 1. Banerjee P, Fazleabas AT: Endometrial responses to embryonic signals in the primate. Int J Dev Biol 2010, 54:295?02. 2. Fishel SB, Edwards RG, Evans CJ: Human chorionic gonadotropin secreted by preimplantation embryos cultured in vitro. Science 1984, 223:816?18. 3. Jurisicova A, Antenos M, Kapasi K, Meriano J, Casper RF: Variability in the expression of trophectodermal markers b.