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Cellularity with lower intracellular iron. Bronchoscopic Rosiglitazone examination with biopsy, brushing and washing found no abnormality. A bone scan was negative for other lesions. There were no metastatic signs in brain and abdomen by CT scan. After the therapy of iron supplement and red blood cell transfusion, Hb was slightly elevated. The patient was transferred for surgery on October, and thoracic CT scan showed the tumor was 55 ?48 mm, with CT value 34 HU, 54 HU in contrast enhancement scanning (Figure 1). After anemia had been cured by transfusion, left exploratory thoracotomy was planned. Operation revealed?2012 Zhou et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Zhou et al. Diagnostic Pathology 2012, 7:112 http://www.diagnosticpathology.org/content/7/1/Page 2 ofFigure PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/15501003 2 Low magnification shows the well-circumscribed tumor with multinodular architecture. ?0.Figure 1 Preoperative radiological features: large mass involving the left upper lobe.a peripheral pulmonary mass on left upper lobe without pleural indentation or swollen lymph node in hilum and mediastinum, and the patient underwent left upper lobectomy with systemic lymph node dissection. The patient recovered smoothly and was discharged in a good condition without anemia after two weeks. Follow-up continued every three month after operation by chest CT scan and CBC. There was no sign of abnormality 32 months after operation. Grossly, the left upper lobe measured 20 cm ?10.5 cm ?4 cm, and the lesion was located in lung parenchyma 2 cm away from the resection margin of left upper bronchus. On cut surface, the tumor measured 5 cm ?5 cm ?3.2 cm in size, pale gray, soft, well demarcated, lobulated with a gelatinous texture. Microscopic examination showed the characteristic features of EMC, including a well-circumscribed, multilobulated architecture separated by incomplete fibrous septae, relatively uniform oval to short spindle shaped cells arranged in short anastomosing strands and cords embedded in abundant myxoid matrix (Figure 2). The cells were characterized by hyperchromatic nucleus and tiny nucleolus, some of which showed grooves (Figure 3). There were a large number of plasma cells and a few lymphocytes in fibrous septae to form the compact zone (Figure 4). No hyaline cartilage was seen. Mitotic figures were 1/50HPF. No infiltration into adjacent lung tissue was seen. Special stains revealed glycogen in the cytoplasm of the tumor cells, while the surrounding extracellularmatrix was positive with Alcian blue stain. By immunohistochemical study, vimentin and NSE were strongly expressed in the tumor cells (Figure 5, 6), while S-100 protein was weak and focal (Figure 7). The other markers including cytokeratin, epithelial membrane antigen (EMA), P63, smooth muscle actin (SMA), muscle specific actin (MSA), desmin, KP1, calretinin were all negative. IFN- was immunopositive in the tumor cells.Discussion EMC has mainly been reported in the areas of orthopedics, neurosurgery, and otolaryngology [1]. As with our case, the characteristic features of well-circumscribed, multilobulated configuration with incomplete fibrous septae, oval to spindle shaped cells arranged in shortFigure 3 High power image of spindle cells in cords present wi.